Alcuni ricercatori stanno scrivendo delle novità sul forum di Rosetta.
Il 24 giugno James Moody ha scritto:
My name is James Moody and I am a new graduate student in the Baker lab. I am working on protein-protein interface design and am excited to have the help of all of the participants of Rosetta@home!
Right now I am working on designing a protein to bind to a regulatory molecule called EED. EED works with other proteins in our cells to control which parts of our DNA will be used to control the cell and which parts will be silenced (turned off). EED is thought to work by bringing other proteins together and is part of a larger protein machine called the Polycomb Repressive Complex 2 (PRC2). PRC2 helps to ensure, for example, that we have the right number of arms and legs and that they are in the right place on our bodies (by controlling our Hox genes).
Engineering this novel interaction with EED into another protein requires computationally screening through as many as possible of a billion possibilities, evaluating each protein for how tightly it sticks to EED, and then redesigning the new protein to stick even better. Such a task would be impossible without the help of Rosetta@home participants!
Thank you so much for lending yourselves to participate in this project. Things that I send to rosetta@home are tested first on our machines and then on a subset of Rosetta@home participants to ensure that they don't cause any problems for you. Please don't hesitate to ask if you have questions, feedback, or see errors.
Il 3 Luglio Eva ha scritto:
Hi everyone,
I am working on another cool project that aims to generate a new molecular tool to dissect bacterial cell division. In order to propagate, cells need to divide. Separation of two daughter cells from a single cell is quite a complicated event that involves a fine-tuned and concerted molecular machinery. It requires figuring out where to actually draw the line, the assemble of several different proteins into one divisosome that will eventually perform the physical separation, and of course on top of all this, the cell needs to keep track of the DNA so that each cell gets its own copy. So it is imaginable that this is a fairly complicated happening.
Thanks for your support! This wouldnt be possible without your help.
Come non "amare" questo progetto, in cui i ricercatori tengono così tanto al rapporto con i volontari??
Ehm, siamo tutti anglofoni, quindi non devo tradurre, nevvero??