ARGOMENTO:

Un'aggiornamento da Malaria...

Status update – December 2011

It’s been a very long time since we last posted an update on the progress we make with your contribution, I apologize for this.

The results and findings of the project have been reported to the scientific community at a number of international conferences by members of our research group, including the European Congress on Tropical Medicine and International Health, the Open Knowledge Conference, and the annual meeting of the Swiss Society of Tropical Medicine and Parasitology. At this time, a delegation is presenting the most recent results at the annual meeting of the American Society of Tropical Medicine and Hygiene.

One more scientific article – on the potential of case management to prevent re-establishment of malaria in areas where it has been eliminated – has just been accepted for publication. Please find a link to this on the publication list at boinc.berkeley.edu/w...ons_by_BOINC_projects#malariacontrol.net if you want to learn more.

Finally, we are planning for an upgrade of the server hardware to host this project. Our current server has been running very reliably for more than four years, but recently we are approaching a capacity limit. Maintenance and monitoring becomes tedious, and we plan to migrate the project to new hardware in Q1 2012.

Thank you for your continued support!
Nick
____________
Nicolas Maire
Swiss Tropical and Public Health Institute
www.swisstph.ch

Aggiornamento di stato - dicembre 2011
E 'passato molto tempo dall'ultima volta che abbiamo pubblicato un aggiornamento sui progressi che facciamo con il vostro contributo, mi scuso per questo. I risultati e le conclusioni del progetto sono stati segnalati alla comunità scientifica in un certo numero di internazionale conferenze da parte di membri del nostro gruppo di ricerca, tra cui il Congresso Europeo di Medicina Tropicale e Salute Internazionale , la Conferenza di Open Knowledge , e la riunione annuale della Società Svizzera di Medicina Tropicale e Parassitologia . In questo momento, una delegazione presenta i risultati più recenti in occasione della riunione annuale della Società Americana di Medicina Tropicale e Igiene . Un articolo più scientifico - sulle potenzialità di gestione dei casi per prevenire ristabilimento della malaria nelle aree in cui è stato eliminato - è appena stato accettato per la pubblicazione. Si prega di trovare un link a questo sulla lista pubblicazione in boinc.berkeley.edu/wiki/Publications_by_BOINC_projects # malariacontrol.net se volete saperne di più. Infine, stiamo progettando per un aggiornamento dell'hardware del server di ospitare questo progetto. Il nostro server corrente ha funzionato molto affidabile per più di quattro anni, ma recentemente ci stiamo avvicinando un limite di capacità. Manutenzione e monitoraggio diventa noioso, e abbiamo intenzione di migrare il progetto a nuovo hardware nel 1 ° trimestre 2012. Grazie per il vostro continuo supporto! Nick ____________ Nicolas Maire tropicale svizzero e Public Health Institute www.swisstph.ch

Oggi ho consegnato una WU (ammetto, un'ora in ritardo, cacchiarola ha impiegato 10 ore a finire!!!) e mi dice "validation inconclusive". Cosa vuol dire???

Ciao!!!

Herr Fritz 27 ha scritto:

Oggi ho consegnato una WU (ammetto, un'ora in ritardo, cacchiarola ha impiegato 10 ore a finire!!!) e mi dice "validation inconclusive". Cosa vuol dire???

Ciao!!!

Per caso l'ha già mandata anche a qualcun'altro, cioè a un terzo scaccolatore?

campos ha scritto:

Per caso l'ha già mandata anche a qualcun'altro, cioè a un terzo scaccolatore?

Scusami, come faccio a vederlo???

Se è sotto la voce "Tasks in progress" mi dice "suppressed pending completion"...

Ciao e grazie!!!

Herr Fritz 27 ha scritto:

campos ha scritto:

Per caso l'ha già mandata anche a qualcun'altro, cioè a un terzo scaccolatore?

Scusami, come faccio a vederlo???

Se è sotto la voce "Tasks in progress" mi dice "suppressed pending completion"...

Ciao e grazie!!!

Allora dovrebbe essere in lavorazione da qualcun altro...

A questo punto bisogna che completi anche lui e poi il sistema tirerà le somme e darà i crediti, se i risultati finali concordano...

campos ha scritto:

Allora dovrebbe essere in lavorazione da qualcun altro...

A questo punto bisogna che completi anche lui e poi il sistema tirerà le somme e darà i crediti, se i risultati finali concordano...

Allora lo terrò d'occhio...

Grazie, ciao!!!

Status Update - March 2012

Link

A breve la traduzione, ci sto lavorando...

campos ha scritto:

Status Update - March 2012

Link

A breve la traduzione, ci sto lavorando...

Articolo Tradotto

Da qualche giorno vengono consegnate tra le altre anche delle wu che durano tantissimo (anche giorni). Nel mio caso le wu iniziano per wu_2952 e wu_2953. Ora dal forum dicono che hanno risolto il problema (ho notato che hanno comunque allungato la validità di tutte le wu da 3 a 6 giorni) ma a me fino a ieri ancora arrivavano.
Le ho dovute abortite perchè mi sconbussolavano il tempo di lavorazione previsto anche delle altre che andavano tutte in priorità alta.

@@$tars_Finder@@ ha scritto:

Da qualche giorno vengono consegnate tra le altre anche delle wu che durano tantissimo (anche giorni). Nel mio caso le wu iniziano per wu_2952 e wu_2953. Ora dal forum dicono che hanno risolto il problema (ho notato che hanno comunque allungato la validità di tutte le wu da 3 a 6 giorni) ma a me fino a ieri ancora arrivavano.
Le ho dovute abortite perchè mi sconbussolavano il tempo di lavorazione previsto anche delle altre che andavano tutte in priorità alta.

Anche a me è successo...

Science update 2013

It’s been a busy year at malariacontrol.net. Much too busy to tell you about the good work you’ve contributed to in just one post. Therefore, this science update comes in three parts, to be published over the next few days.

This first post we’ll talk about some work that was published last fall, looking at how best estimate the amount of malaria in low transmission settings.

Malaria transmission is governed by many things, but when scientists are talking about transmission, they are generally thinking of the entomological inoculation rate [EIR], that is, the average number of infected mosquito bites a person receives in a year. In some of the worst malarial areas, this number can easily be in the hundreds of bites per year.

EIR is generally measured by trapping mosquitos and seeing what percentage of them are infected with malaria and then factoring in the number of bites they give a night. For example, a catch of 20 Anopheles per person per night, where 80% are human-fed and 10% are infected with malaria sporozoites would correspond to an EIR of 20 x 0.80 x 0.1 = 1.6. Each individual in that area receives 1.6 infective bites per night or an annual EIR 584. But when the transmission rate is very low (which is, in and of itself, a good thing), you would have to trap a lot more mosquitos to get a reliable estimate of the percentage of them carrying malaria. It’s harder to measure the actual transmission rate at low EIR and it’s also harder to model what happens at those low EIRs.

Erin Stuckey at the Swiss TPH used your help to explore transmission dynamics in a low-transmission setting: the Rachuonyo South highlands above the shores of Lake Victoria in Kenya. One of the reasons we run models is to try to understand which factors have the most impact on outcome of interest (in this case, malaria control). She found that key issues for Rachuonyo were to vector biting behaviour, their susceptibility to IRS, and the detection method used for human surveys – all of these affect the impact of interventions in areas with low and/or variable P. falciparum transmission.

Erin also looked the impact of the measurement method on the estimate EIR in low transmission settings. She created an experiment that mimiced the detection limits of polymerase chain reaction (PCR), skilled microscopy, and a low-quality diagnostic such as a poor-quality RDT or unskilled microscopy. The number of simulated infections decreases with higher detection limits, as does the stochasticity of the predictions.

That’s our problem in a nutshell, not only is it more difficult to measure the amount of malaria in low transmission areas, the estimates themselves vary widely due to natural variability.

Decision makers need guidance on where to best put their efforts at malaria control. The take home message of this work is that we need simulations even when (or perhaps especially when) the field data are sparse in order to make decisions. We also learned that measuring EIR through mosquito collection may not be the optimal way to define transmission in areas with low, unstable transmission.

As always, thanks for you good work and volunteer resources. We really couldn't do it without you!

Mariah Silkey [/img]
____________
Mariabeth Silkey
Swiss Tropical and Public Health Institute
www.swisstph.ch

Link all'articolo

Scienze update (in 3 parti) dei risultati sin qui ottenuti sulla home page del progetto

www.malariacontrol.net

K.

Hanno aggiornato l'applicativo e lo stanno testando:

Dear users,
As of today, I am updating the malaria control test application to OpenMalaria v32 (see previous news item). Also today, I will be starting a small experiment using this simulator version of roughly 17000 workunits.

With this release comes support for an extra platform: 64-bit Windows (previously, the 32-bit Windows application was used on both 32-bit and 64-bit Windows). This build requires the .NET framework and has so far only been tested on Windows 7 and 8.1, so let us know if you run into any issues.

Così tanti progetti, così poche cpu appena finisce il challenge di seti mi metto sotto

Mi ero perso questa news polposa...

Link

Dear malariacontrol.net supporters,

It has been some time since we sent you a science post, not because we haven't been busy, quite the contrary.

But before sharing exciting science, we'd like to express our deep gratitude for your continued support and computational time.

Thank you!

We had a busy few years working on important topics in malaria research and global health: from vector control strategies in pre-elimination countries, to optimization of malaria control tools in support of the Global Fund applications, to key analyses for policy decisions on malaria vaccines. Just to name a few.

Here are some recent articles we would like to share with you:

Malaria Vaccines:
You may have read recently in the news that the world may be close to the first malaria vaccine being approved for use in sub-Saharan Africa. The European Medicines Agency (EMA) adopted a positive scientific opinion for the malaria vaccine RTS,S, also known as Mosquirix, in children aged 6 weeks to 17 months. This is a key step in the regulatory process towards making RTS,S available for the population at risk of malaria in sub-Saharan Africa. The next step involves WHO reviewing the evidence base for RTS,S and making a policy recommendation for if and how this vaccine should be used alongside other tools to prevent malaria in different endemic settings. The policy recommendation is meant to provide technical guidance to endemic countries considering the vaccine introduction. The WHO has indicated that such a policy recommendation may be possible still in 2015.

The modelling team and your work contributed to assessment of the vaccine in terms of its expected public health impact and cost- effectiveness, providing information in addition to the clinical trial data.

Some of this work was recently published
"The public health impact of malaria vaccine RTS,S in malaria endemic Africa: country-specific predictions using 18 month follow-up Phase III data and simulation models"
by Melissa Penny and our team at Swiss TPH

You can access the article here:
www.biomedcentral.com/1741-7015/13/170

Thanks for your help!

Malaria Dynamics
We also recently published on another important issue: reasons for potential shift of burden to older ages with partially effective malarial interventions. Simulations from OpenMalaria were used to address this, so we thank you for your support.

"Age-shifting in malaria incidence as a result of induced immunological deficit: a simulation study"
by Peter Pemberton-Ross in our modelling team at Swiss TPH

You can access the article here:
www.malariajournal.com/content/14/1/287


Cost Effectiveness of Malaria Control Interventions
Tools that allow for in silico optimization of available malaria control strategies can assist decision-making process for prioritizing interventions.

One such example :
"Modeling the Cost Effectiveness of Malaria Control Interventions in the Highlands of Western Kenya"
by Erin Stuckey previously with our modelling team at Swiss TPH

you can access the article here:
journals.plos.org/pl.../article?id=10.1371/journal.pone.0107700

Again thank you for your continued support and volunteering computer time!

Best regards,
Melissa Penny and the malaria modelling team at Swiss Tropical and Public Health Institute.

Tanta roba veramente!!! Bobo le pubblicazioni!!!!

Dal sito, (notizia datata oggi):

Dear malariacontrol.net community, Apologies for not responding sooner to the lack of work-units for malariacontrol.net. We had some technical problems with our attempts to fit improved models of malaria dynamics to field data. This meant that we had to close down the generation of new work units. We hoped that this would be a very short term problem, but over Christmas and the New Year, it was difficult to assess exactly what was going on. Unfortunately we are now faced with the challenge that for a variety of personal reasons the team members able to address these problems are currently not available, and we don’t have any spare funding that we can allocate to hiring anyone new. We are now almost at the 10th anniversary of malariacontrol.net and we are really hoping to keep this going, but it will probably be another month or two before we can get the system up again. Malariacontrol.net has now been going for ten years, and your contributions to this over the years have been really useful- (take a look at github.com/SwissTPH/openmalaria/wiki ). Instead of this apology, we would really like to be sending you all a big thank you!

Sono senza soldi e non possono cercare altro personale.
Chissà se riusciranno ad andare avanti !!!

Sarebbe un vero peccato se dovessero chiudere dopo 10 anni. Attendiamo uno o due mesi e speriamo bene!

Talon ha scritto:

Sarebbe un vero peccato se dovessero chiudere dopo 10 anni. Attendiamo uno o due mesi e speriamo bene!

Anche in passato è capitato che il progetto si sia fermato per diversi mesi... speriamo sia solo una cosa passeggera e si riesca a trovare una soluzione...

Dal sito

Status and plans as of June 2016
Dear Malariacontrol.net contributor,

It's been a while since we announced that malariacontrol.net will be back after a short period of maintenance and upgrading, and you are probably wondering why you are still not receiving new workunits.

By now, it looks like malariacontrol.net will not be sending out workunits any time soon. The reason for this is that, unlike when we started out more than ten years ago, volunteer computing is currently not the most efficient and cost-effective approach for providing the computing resources necessary for the simulation studies. Developments in high-performance computing and institutional arrangements have made computing infrastructure accessible to the malaria modeling project which was simply not available ten years ago. Also, the staffing profile of the project has changed over time, and maintenance and further development of the volunteer computing platform are more challenging these days than before. Therefore, at the moment we cannot justify the significant investment required to upgrade the malariacontrol.net-specific components of the BOINC server for the next phase of the project.

This is a good moment to look back on more than 10 years of running malariacontol.net, and the achievements you contributed to. We believe that the project has substantially improved knowledge of malaria and malaria control. The scientific articles which are listed on the BOINC wiki give an overview of the achievements. In addition, some of the simulation experiments we ran on malariacontrol.net have formed the basis of technical reports and software tools which helped inform important policy decisions.

We will keep the malariacontrol.net server running for now. It may be that sometime in the future, we will have applications that will make this again the best way for running simulations, so please keep your BOINC client connected to malariacontrol.net.

Thank you very much for your generous support over the last 10 years!

On behalf of the malaria modeling team,

Nicolas
-- 21 Jun 2016 14:34:35 UTC

Sembra più un addio che un arrivederci