Valutazione attuale: 5 / 5

Stella attivaStella attivaStella attivaStella attivaStella attiva


AMBITO: Biologia, Medicina
VOTO: ( N.P. )


The Plasmodium falciparum genome has been sequenced, the proteome has been mapped, and protein expression has been confirmed at various stages in this apicoplexan's life cycle. Numerous crystal structures of target proteins are also available, and the remainder have been modelled using available structural templates. Excitingly, large research organisations (GSK, Novartis) have already tested millions of compounds and found nearly 19,000 hits that show promising activity against Plasmodium falciparum [MMV]. But they don't know which target protein is inhibited by these compounds. Drug discovery and development will be significantly enhanced by knowing the target protein for each of these hits.
We plan to dock each of the 18,924 hits into structures of each of the 5,363 proteins in the malaria parasite. The computational power needed is enormous..

Per ulteriori informazioni visitate il thread ufficiale presente nel nostro forum.

Per commentare questo post nel forum devi effettuare il login


Written on 11/02/2020, 21:20 by sabayonino
boinc-radio-podcast     Da poco è nato il Radio podcast dedicato a BOINC.     BOINC Network's weekly participatory podcast discussing BOINC, science, and distributed...

Ultime dal Blog

Written on 16/09/2019, 09:51 by boboviz
ci-vuole-un-fisico-bestiale-per-andare-al-cernCome alcuni di voi sapranno, periodicamente, il CERN apre i suoi portoni alla visita di chi vuole andarci e la cosa viene chiamata OpenDays. Questa volta...