ARGOMENTO:

HPF2 Update - March 2010

Greetings WCG Volunteers,

We've been working diligently to develop a pipeline for a cooperative analysis of phylogenetic and structural data. We will integrate our structure predictions with knowledge of how proteins (and functional sites on folded proteins) evolve, by estimating the phylogenies of all protein domain families in our database and identifying positively-selected amino acid sites in these families using codon-based molecular evolution models that can be mapped onto the predicted structures. The first stages of this analysis are coming to fruition, and we've begun investigating preliminary results.

Using phylogenetic models, we intend to identify sites of proteins exhibiting evolutionary pressure. This may improve our understanding of how proteins evolve new functions and structures, and will ultimately lead to an increase in genome annotation for proteins whose purpose we know next to nothing about. The great scale of and wealth of information in our database may allow us to improve upon our existing and future de novo structure and function predictions. Identifying structurally or functionally importing residues in protein domains should inform our comparative modeling techniques. We use probabilistic methods to produce models of evolution using observed rates of mutation in protein families. Lots of different evolutionary pressures affect the mutation and expression of proteins, but we hope to garner insight with this analysis about how evolution adapts protein function.

Using our automated methods, we produced evolutionary models for a handful of identified protein domain families in major plant genomes. One such protein family matches PDB 1TQE "Myocyte Enhancer Factor-2". While this analysis is very preliminary (and I stress preliminary), positive selection analysis identifies a few residues that may be involved in DNA binding and the integrity of the dimer near the substrate. This is the kind of science we'll be investigating in the future using WCG predicted structures.
--
Patrick Winters
Bonneau Lab

Iscritto!

Ragazzi una domanda al volo: quando lo status riporta il messaggio "Pronto da riportare" si può forzare in qualche modo il report oppure fa tutto da solo?
Perchè ne ho 2 lì da stamattina, sono ancora in attesa...

Abbiate pietà sono un niubbone totale

Saluti

13 Apr 2010 – Il progetto Nutritious Rice for the World è concluso

World Community Grid è lieta di annunciare che, quale risultato dei generosi contributi degli utenti in termini di potenza computazionale, il progetto Nutritious Rice for the World è giunto al termine il 6 aprile 2010.

13 Apr 2010

End of Nutritious Rice for the World project

Category: Nutritious Rice for the World
Tags: Project Event

Summary
World Community Grid is pleased to announce, that as a result of the generous contribution of computing power from our members, the Nutritious Rice for the World project finished on April 6, 2010.



Nutritious Rice for the World Research Project Completion

Member News

World Community Grid is pleased to announce that as a result of the generous contribution of computing power from our members, the Nutritious Rice for the World project finished on April 6, 2010.

The project was launched on May 12, 2008. While it was active, World Community Grid members processed over 29 million results which required nearly 26,000 years of computing power. This work would have taken about 200 years of time using the computing resources available to the researchers at the University of Washington. Using World Community Grid, this research was completed in less than two years.

With this project's completion, our members have significantly contributed to the research that is being done to ultimately develop rice strains that will make a difference in fighting malnutrition and feeding the world’s people.

Now comes the difficult part of sifting through the data to find the best models. The researchers need to find the best models from the almost 7 billion models generated. This should take approximately 3-6 months using their fastest methods. After identifying the most accurate models, they will use the information to figure out what functions these proteins perform in the rice organism. This involves comparing the structure and sequence to known proteins which is also a time consuming process. The plant genomes are not nearly as well studied as the human and mammalian genomes which makes the process all the more difficult.

You may read about these plans and get the latest update from The Nutritious Rice for the world scientists in this forum thread or on their website.

The Nutritious Rice for the World research staff at the University of Washington, USA wish to express their sincere gratitude to you for contributing your computer power to this project.

We still need your help with six (6) other ongoing projects! World Community Grid continues to run the following projects: FightAIDS@Home, Help Conquer Cancer, Help Cure Muscular Dystrophy - Phase 2, Help Fight Childhood Cancer, Human Proteome Folding - Phase 2, and Discovering Dengue Drugs – Together, Phase 2. All of these important projects need your computer time. If you only had Nutritious Rice for the World selected for active projects, then you will start receiving work from the other active projects. To modify your project selection criteria, please go to the My Projects Page.

World Community Grid in Fast Company Magazine!

World Community Grid is the subject of a terrific article in the May 2010 issue of Fast Company magazine. The writer takes an in-depth look at key World Community Grid projects, and how hundreds of thousands of volunteers are banding together to help the world by enabling life-saving scientific research. You can read the article here . (registration to the website is free)

03 May 2010

Dr. Alessandra Carbone named "Woman Scientist of the Year"

Category: Help Cure Muscular Dystrophy - Phase 2
Tags: Video and Media

Summary
Dr. Alessandra Carbone, Principal Investigator for the Help Cure Muscular Dystrophy project, was recently honored as "Woman Scientist of the Year".


Dr. Alessandra Carbone, professor at Université Pierre et Marie Curie (UPMC) and Principal Investigator for the Help Cure Muscular Dystrophy project, was recently honored as "Woman Scientist of the Year" by the jury of the 9th Irène Joliot-Curie Prize from the French Department of Higher Education and Research.

raga come faccio a fare il merge di due hosts su WCG? non sono riuscito a farlo da mio account
grazie!