ARGOMENTO:

Appena visto sul sito:

NOTE: THere has been a problem uploading this to the server (something went wrong with signing the app),
we are currently trying to resolve this - sorry for the outage, we'll try and have this fixed ASAP.

Qualcuno gli ha anche risposto che non si fanno gli aggiornamenti il fine settimana...

I know I'm being wise after the event, but releasing a new version last thing on a Friday afternoon (midnight UK for my first download) is just asking for trouble. A disproportionate number of problems occur on weekends or in holidays when there's never going to be anyone around to start clearing it up until Monday. We've all seen that a few times.
You aren't doing yourselves any favours.

Problema risolto con la versione 1.87
Ci sono pure le scuse sul sito....

che bestia quel tizio

Venturini Dario ha scritto:

che bestia quel tizio

Eh, già...ma i nodi vengono prima o poi al pettine..
Dalla pagina del sito:

Due to a massive slowing down of the lastest code, we reverted the application back to a version equivalent to 1.82, while we work on the code. Sorry about the outage.

Non capisco.
Prima dicono che per vari problemi tornano alla versione 1.82
Ma io sto scaccolando la versione 1.88 su tutti i miei criceti!!
Un casino tipo Lost....

E sul forum si lamentano in molti della 1.88

boboviz ha scritto:

E sul forum si lamentano in molti della 1.88

Effettivamente anche il sottoscritto sta segnando il suo record personale di wu con errori...
Il download/upload rimane lentissimo
Quasi quasi fermo tutto e mi ricollego tra un paio di giorni...

Il dowload/upload sarà lentissimo perchè tutti chiedono WU che poi vanno in errore e poi le restituiscono subito...

A me comunque 2 su 3 in errore oggi

Sono appena tornato a rosetta.. E anche io pieno pieno di problemi!

Errori anche da me sulle 1.88...

Sul sito di Rosetta ci sono un pò di spiegazioni
E hanno fatto uscire pure la 1.90 (dopo un disastroso passaggio su Ralph)...

Confermo che ora la situazione è a posto, forse un po' lenta. Nelle news tradotte trovate tutto, compresi i link alle discussioni

Comunque posso anticiparvi che tutto il casino è nato per errore umano

come sempre...le macchine eseguono ciò che gli viene ordinato!!!

Non c'è verso però... continua a darmi "download fallito"

E' uscita la versione 1.91 per ovviare al problema delle firme...

A number of users are still getting signature verification errors with the database file so we've updated the minirosetta application to version 1.91 with a new database filename. 1.91 is a copy of 1.90 with the only difference being a new name for the database file to ensure that every host updates the signature

Dovrebbe essere tutto risolto ora

Comunque io apparte i problemi ai server, per il resto sempre tutto ok

David Baker:

We got very good news today--the paper I described to you several months ago was finally accepted for publication in Nature, one of the most widely read science journals.

The manuscript describes the design of new enzymes for use ultimately in gene repair. Suppose you have a mutation in your genome that causes you to have a disease. If you know where the mutation is, in principle it can be repaired by "cutting out" the bad information (the mutation) and replacing it with the correct DNA sequence in this region. To do the cutting out is tricky because you only want to cut right near the mutation, and not anywhere else within your 3 billion base genome.

We are developing computational methods using Rosetta to design new enzymes to do this very highly specific "cutting". In this manuscript, we show that we can now design new specific cutting enzymes and that we can control independently how fast they cut and how tightly they bind to the target sequences we design them to cut.

Hopefully you will be able to read about this soon at your local newsstand!

Fantastico e terribilmente pericoloso... Ma d'altra parte stiamo scaccolando per questo, e questi sono i risultati che vogliamo sentire!

Uao

David Baker:

We just learned that a model we had generated using the "fold and dock" method on your computers allowed the solution of the phase problem for structural biologists who had grown crystals of the (dimeric) protein but not been able to solve its structure--this result led to a huge flurry of email today as the approach could be very useful for a broad class of problems.

As I mentioned earlier, the paper on the "fold and dock" protocol (which you can recognize by the symmetric dancing of molecules on your screensaver) was enthusiastically accepted for publication in the proceedings of the national academy of sciences and will be free on line soon. Here is one of the anonymous reviews of the manuscript:

"The authors introduce a simultaneous "fold and dock" routine for the prediction of symmetric systems with impressive results. The method combines the Rosetta folding algorithm and the lab's more recent symmetric docking protocol. Here, both the backbone moves and relative positioning of the components are accomplished in the same Monte Carlo routine. Undoubtedly, this feature is necessary for most of the systems, particularly those which are intertwined. The authors both benchmark their results and even include a few predictions (using structures that came out after simulations). In addition they test the utility of the method for ab initio phasing and structure prediction incorporating some NMR-based constraints. This is an extremely nice piece of work which addresses an outstanding challenge in structural biology and protein structure prediction."